2022-present
S Xu, JC Smothers, D Rye, S Endapally, S Li, G Liang, M Kinnebrew, R Rohatgi, B Posner, A Radhakrishnan. A cholesterol-binding bacterial toxin provides a strategy for identifying a Scap inhibitor that blocks lipid synthesis in animal cells. PNAS, 2023. PMID: 38330014
CB Khandwala*, P Sarkar*, HB Schmidt, M Ma, M Kinnebrew, GV Pusapati, BB Patel, D Tillo, AM Lebensohn, R Rohatgi. Direct ionic stress sensing and mitigation by the transcription factor NFAT5. bioRxiv, 2023. PMID: 37886503
TB Ansell, RA Corey, LV Viti, M Kinnebrew, R Rohatgi, C Siebold, MSP Sansom. The energetics and ion coupling of cholesterol transport through Patched1. Science Advances, 2023. PMID: 37611095
CT Han, KDQ Nguyen, MW Berkow, S Hussain, A Kiani, M Kinnebrew, MN Idso, N Baxter, E Chang, E Aye, E Winslow, M Rahman, S Seppälä, MA O'Malley, BF Chmelka, B Mertz, S Han. Lipid membrane mimetics and oligomerization tune functional properties of proteorhodopsin. Biophysical Journal, 2023. PMID: 36352784
M Kinnebrew, RE Woolley, TB Ansell, EFX Byrne, S Frigui, G Luchetti, R Sircar, S Nachtergaele, L Mydock-McGrane, K Krishnan, S Newstead, MSP Sansom, DF Covey, C Siebold, R Rohatgi. Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Science Advances, 2022. PMID: 35658032
2018-2021
M Kinnebrew, G Luchetti, R Sircar, S Frigui, LV Viti, T Naito, F Beckert, Y Saheki, C Siebold, A Radhakrishnan, R Rohatgi. Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. Elife, 2021. PMID: 34698632
M Kinnebrew*, KA Johnson*, A Radhakrishnan, R Rohatgi. Measuring and manipulating membrane cholesterol for the study of Hedgehog signaling. Methods in Molecular Biology, 2021. PMID: 34562244
D Gokhman, RM Agoglia, M Kinnebrew, W Gordon, D Sun, VK Bajpai, S Naqvi, C Chen, A Chan, C Chen, DA Petrov, N Ahituv, H Zhang, Y Mishina, J Wysocka, R Rohatgi, HB Fraser. Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nature Genetics, 2021. PMID: 33731941
M Kinnebrew*, EJ Iverson*, BB Patel, GV Pusapati, JH Kong, KA Johnson, G Luchetti, KM Eckert, JG McDonald, DF Covey, C Siebold, A Radhakrishnan, R Rohatgi. Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. Elife, 2019. PMID: 31657721
AF Rudolf*, M Kinnebrew*, C Kowatsch, TB Ansell, K Omari, B Bishop, E Pardon, RA Schwab, T Malinauskas, M Qian, R Duman, DF Covey, J Steyaert, A Wagner, MSP Sansom, R Rohatgi, C Siebold. The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature Chemical Biology, 2019. PMID: 31548691
C Kowatsch*, RE Woolley*, M Kinnebrew, R Rohatgi, C Siebold. Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and hedgehog signaling. Current Opinion in Structural Biology, 2019. PMID: 31247512
GV Pusapati*, JH Kong*, BB Patel, A Krishnan, A Sagner, M Kinnebrew, J Briscoe, L Aravind, R Rohatgi. CRISPR screens uncover genes that regulate target cell sensitivity to the morphogen Sonic hedgehog. Developmental Cell, 2018. PMID: 29290584
2013-2016
A Pavlova, CY Cheng, M Kinnebrew, J Lew, F Dahlquist, S Han. Protein structural and surface water rearrangement constitute major events in the earliest aggregation stages of tau. Proceedings of the National Academy of Sciences, 2016. PMID: 26712030
S Hussain, M Kinnebrew, NS Schonenback, E Aye, S Han. Functional consequences of the oligomeric assembly of proteorhodopsin. Journal of Molecular Biology, 2015. PMID: 25597999
DT Edwards, T Huber, S Hussain, K Stone, M Kinnebrew, I Kaminker, E Matalon, MS Sherwin, D Goldfarb, S Han. Determining the oligomeric structure of proteorhodopsin by Gd3+- based pulsed dipolar spectroscopy of multiple distances. Cell Press Structure, 2014. PMID: 25438671
KM Stone, J Voska, M Kinnebrew, A Pavlova, S Han. Structural insight into proteorhodopsin oligomers. Biophysical Journal, 2013. PMID: 23442869
*Authors contributed equally to this work
